Formic Acid → N[4(1-fluoromethyl-ethyl)phenyl]-formamide
Reaction equation
[F:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)[CH3:4].[CH:12](O)=[O:13]>C1(C)C=CC=CC=1>[F:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][CH:12]=[O:13])=[CH:7][CH:6]=1)[CH3:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 20 g (0.13 Mol) of 4(1-fluoromethyl-ethyl)benzeneamine and 6 g (0.13 Mol) of 98% formic acid in 150 ml of dry toluene is boiled under reflux. When 2.5 ml of water have separated in the water trap, an additional 6 g of formic acid are added and refluxing is continued until no more water and formic acid separate.
Workup
- temperatureunder reflux
- customWhen 2.5 ml of water have separated in the water trap
- additionan additional 6 g of formic acid are added
- temperaturerefluxing
- customseparate
Sources & evidence
- ORD record
- ord-fd676d0f19d94e62a36ed75b5f9c45ae
- Source dataset
- uspto-grants-1986_04
- Patent number
- US04579585
Reaction notes
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