HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-Butyl-3-isopropyl-6-chlorouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Butyl-p-toluenesulfonate | HCID 13066 | — |
| Reactant | 6-Chloro-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 820107 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Butyl-3-isopropyl-6-chlorouracil | HCID 23326877 | 98.1% |
Reaction Steps
16.6 g (0.12 mole) of potassium carbonate and 24 g (0.105 mole) of butyl-p-toluene sulphonate are added to a solution of 19 g (0.10 mole) of 3-isopropyl-6-chlorouracil in 200 ml of dimethyl formamide. The mixture is heated for 1 hour to 80° C. After evaporation of the solvent, the residue is taken up in water, followed by extraction with CH2Cl2. The extract is dried over Na2SO4 and the solvent is evaporated, leaving 24 g of a pale yellow oily product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04581451 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-5b58ab43a8f7478da0398adfb7584e49 |
| Source note | uspto-grants-1986_04 |