4,5-Diaminopyrimidine → 2-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride

HRID 1380720

Reaction equation

HRID 1380720 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.[NH2:16][C:17]1[C:22]([NH2:23])=[CH:21][N:20]=[CH:19][N:18]=1>>[ClH:15].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[N:16]=[C:17]2[C:22]([NH:23][CH:19]=[N:18]2)=[CH:21][N:20]=1

Participants

3

Reactant 2

HCID 837034,5-DiaminopyrimidineHCID 201845804-(Chlorosulfonyl)-2-methoxybenzoic acid

Product 1

HCID 201845292-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride

Procedure

Prepared analogously to Example C from 2.5 gm of 2-methoxy-4-chlorosulfonyl benzoic acid and 2.4 gm of 4,5-diamino-pyrimidine (crystalline product obtained from dihydorchloride and 1 mol of common salt) by refluxing for eight hours. The solid crude product was processed further without any purification.

Workup

  1. temperatureby refluxing for eight hours
  2. customThe solid crude product was processed further without any purification

Sources & evidence

ORD record
ord-6d842c7706d44ef9bc1746be111d8ca0
Source dataset
uspto-grants-1986_04
Patent number
US04582837

Linked notes

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