4,5-Diaminopyrimidine → N-[3-Methoxy-4-(7H-purin-8-yl)phenyl]methanesulfonamide

Reaction equation

[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][N:5]=[CH:4][N:3]=1.[CH3:9][O:10][C:11]1[CH:19]=[C:18]([NH:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH:17]=[CH:16][C:12]=1[C:13](O)=O>>[CH3:9][O:10][C:11]1[CH:19]=[C:18]([NH:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH:17]=[CH:16][C:12]=1[C:13]1[NH:8][C:7]2[C:2](=[N:3][CH:4]=[N:5][CH:6]=2)[N:1]=1

Participants

Reactant 2

HCID 837034,5-Diaminopyrimidine

HCID 121193062-Methoxy-4-[(methylsulfonyl)amino]benzoic acid

Product 1

HCID 13284519N-[3-Methoxy-4-(7H-purin-8-yl)phenyl]methanesulfonamide

Procedure

Prepared analogously to Example 14 from 4,5-diaminopyrimidine and 2-methoxy-4-methanesulfonylamino-benzoic acid.

Sources & evidence

ORD record: ord-ac371a45fb40466bb917e02215e90103
Source dataset: uspto-grants-1986_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04582837

Reaction notes

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