4,5-Diaminopyrimidine → N-[2-Methoxy-4-(7H-purin-8-yl)phenyl]methanesulfonamide

Reaction equation

[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][N:5]=[CH:4][N:3]=1.[CH3:9][O:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=1[NH:20][S:21]([CH3:24])(=[O:23])=[O:22])[C:14](O)=O>>[CH3:9][O:10][C:11]1[CH:12]=[C:13]([C:14]2[NH:8][C:7]3[C:2](=[N:3][CH:4]=[N:5][CH:6]=3)[N:1]=2)[CH:17]=[CH:18][C:19]=1[NH:20][S:21]([CH3:24])(=[O:23])=[O:22]

Participants

Reactant 2

HCID 837034,5-Diaminopyrimidine

HCID 201845274-[(Methanesulfonyl)amino]-3-methoxybenzoic acid

Product 1

HCID 13284524N-[2-Methoxy-4-(7H-purin-8-yl)phenyl]methanesulfonamide

Procedure

Prepared analogously to Example 14 from 4,5-diaminopyrimidine and 3-methoxy-4-methanesulfonylamino-benzoic acid.

Sources & evidence

ORD record: ord-d96da8f002d94b48845f4c540a649f0b
Source dataset: uspto-grants-1986_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04582837

Reaction notes

Loading…