Reaction equation
ClC1C=C2C(C(=O)CCN2)=CC=1.[Cl:13][C:14]1[CH:15]=[C:16]([CH:23]=[CH:24][CH:25]=1)[NH:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21].[C:26](Cl)([Cl:28])=[O:27]>>[Cl:28][C:26]([N:17]([CH2:18][CH2:19][C:20]([OH:22])=[O:21])[C:16]1[CH:23]=[CH:24][CH:25]=[C:14]([Cl:13])[CH:15]=1)=[O:27]Participants
4
Procedure
A process of the preparation of 7-chloro-1,2,3,4-tetrahydro-4-quinolinone which comprises treating 3-(m-chloro-anilino)propionic acid with phosgene to produce N-chloroformyl-3-(m-chloroanilino)propionic acid, converting the said product, by the action of an organic base or by heating, into 3-(m-chlorophenyl)-2,6-dioxo-1,3-perhydrooxazine, and treating the latter with aluminium chloride in an inert organic solvent or with a strong acid, to provide 7-chloro-1,2,3,4-tetrahydro-4-quinolinone.
Sources & evidence
- ORD record
- ord-747c8bb1ce0746fdad3b5d4d2ff2a4d4
- Source dataset
- uspto-grants-1986_04
- Patent number
- US04585867
Linked notes
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