Methyl 4-(1H-imidazol-1-yl)benzoate → N-[2-[Bis-(phenylmethyl)amino]ethyl]-4-(1H-imidazol-1-yl)-benzamide hemihydrate
Reaction equation
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[CH:6][CH:5]=1.[CH2:16]([N:23]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:24][CH2:25][NH2:26])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[OH2:2].[C:28]1([CH2:27][N:23]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:24][CH2:25][NH:26][C:3](=[O:15])[C:4]2[CH:5]=[CH:6][C:7]([N:10]3[CH:14]=[CH:13][N:12]=[CH:11]3)=[CH:8][CH:9]=2)[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1.[C:17]1([CH2:16][N:23]([CH2:24][CH2:25][NH:26][C:3](=[O:15])[C:4]2[CH:5]=[CH:6][C:7]([N:10]3[CH:14]=[CH:13][N:12]=[CH:11]3)=[CH:8][CH:9]=2)[CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1Participants
3
Procedure
Heat 4.23 g (21.0 mmol) of 4-(1H-imidazol-1-yl)benzoic acid methyl ester and 5.00 g (21.0 mmol) of N,N-dibenzylethylenediamine in 10 mL of xylenes at reflux for about 48 hr. Cool the solution to room temperature. Filter to obtain crystals of the title compound.
Workup
- temperatureat reflux for about 48 hr
- filtrationFilter