Sulfamic Acid → Acesulfame

HRID 1381973

Reaction equation

HRID 1381973 reaction equation
[C:1]([NH2:7])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[S:8](=O)(=[O:11])([OH:10])N>>[CH3:5][C:3]1[O:4][S:8](=[O:11])(=[O:10])[NH:7][C:1](=[O:6])[CH:2]=1

Participants

3

Reactant 2

HCID 5987Sulfamic Acid2×HCID 80077Acetoacetamide

Product 1

HCID 36573Acesulfame

Procedure

cyclizing the acetoacetamide derivative; the process comprises using, as the sulfamic acid derivative in stage (a), a salt of sulfamic acid which is at least partly soluble in the inert organic solvent employed, cyclizing the acetoacetamide-N-sulfonate formed in this stage or the free acetoacetamide-N-sulfonic acid in stage (b) by the action of an at least approximately equimolar amount of SO3, if appropriate in an inert inorganic or organic solvent, to give 6-methyl-3,4-dihydro-1,2,3-oxa-thiazin-4-one 2,2-dioxide, and then, if desired, also neutralizing with a base, in a stage (c), the product obtained here in the acid form.

Workup

  1. customformed in this stage

Sources & evidence

ORD record
ord-a6387a52fe2d426d8c8d1b4273ed9d87
Source dataset
uspto-grants-1989_02
Patent number
US04804755

Linked notes

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