Veratrole → HCID 11087524, compound

HRID 1383299

Reaction equation

HRID 1383299 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH3:10].[Cl-].[Cl-].[Cl-].[Al+3].[C:15]1(=[O:25])[O:20][C:18](=[O:19])[C@H:17]2[CH2:21][CH:22]=[CH:23][CH2:24][C@@H:16]12>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH:6]=[CH:5][C:4]=1[O:9][CH3:10])[C:15]([C@H:16]1[CH2:24][CH:23]=[CH:22][CH2:21][C@H:17]1[C:18]([OH:20])=[O:19])=[O:25]

Participants

5

Reactant 3

HCID 7043VeratroleHCID 98495Tetrahydrophthalic anhydride, cis-HCID 6451240Aluminum(III) Chloride

Product 1

HCID 11087524HCID 11087524, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.5 mole of 1,2-dimethoxybenzene was added slowly to a suspension of 0.5 mole aluminiumtrichloride in 1 l of dichloromethane at 0° C. After complete addition, cis-1,2,3,6-tetrahydrophthalic acid anhydride was added to the solution. After 8 hours of reflux the solution was poured onto ice. The organic layer was dried over magnesium sulfate and evaporated. The residue was washed with diethyl ether and dried. M.p. 110-112° C.

Workup

  1. additionwas added to the solution
  2. temperatureAfter 8 hours of reflux the solution
  3. additionwas poured onto ice
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. customevaporated
  6. washThe residue was washed with diethyl ether
  7. customdried

Sources & evidence

ORD record
ord-374b144bb16f4fd39577162cc8f03fcb
Source dataset
uspto-grants-2001_07
Patent number
US06255303B1

Linked notes

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