Chloroacetyl chloride → 2-chloro-N-(6-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-3-cyanopyridin-2-yl)-N-isobutylacetamide
Reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([NH:15][CH2:16][CH:17]([CH3:19])[CH3:18])[C:12]([C:20]#[N:21])=[CH:11][C:10]=1[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=1.[Cl:29][CH2:30][C:31](Cl)=[O:32]>>[Cl:29][CH2:30][C:31]([N:15]([C:13]1[C:12]([C:20]#[N:21])=[CH:11][C:10]([C:22]2[CH:23]=[CH:24][C:25]([Cl:28])=[CH:26][CH:27]=2)=[C:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[Cl:1])[N:14]=1)[CH2:16][CH:17]([CH3:19])[CH3:18])=[O:32]Participants
3
Procedure
The product of Step A was reacted with chloroacetyl chloride using conditions similar to EXAMPLE 62 Step A to afford the title compound. HPLC/MS: 489.9 (M+1), 491.8 (M+3); Rt=4.40 min.
Sources & evidence
- ORD record
- ord-38b814c969384b8a992cbe56fb2e00bb
- Source dataset
- uspto-grants-2010_06