2-Chloro-6,7-dimethoxy-4-quinazolinamine → 6,7-Dimethoxyquinazoline

HRID 1384955

Reaction equation

HRID 1384955 reaction equation
C1(C(N2CCNCC2)=O)CCCCC1.Cl[C:16]1[N:25]=[C:24](N)[C:23]2[C:18](=[CH:19][C:20]([O:29][CH3:30])=[C:21]([O:27][CH3:28])[CH:22]=2)[N:17]=1>>[CH3:28][O:27][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][C:20]=1[O:29][CH3:30])[N:17]=[CH:16][N:25]=[CH:24]2

Participants

3

Reactant 2

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 34375021-(Cyclohexylcarbonyl)piperazine

Product 1

HCID 30316616,7-Dimethoxyquinazoline

Procedure

N-(Cyclohexylcarbonyl)piperazine (5.9 g., 0.03 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (7.2 g., 0.03 mole) are reacted according to the procedure of Example 127(a). The crude product crystallized from methanol affords analytically pure 4-amino-2-4-(cyclohexylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline, m.p. 223°-225° C., resolidifying and remelting at 248.0°-250.0° C. (corr.)

Workup

  1. customThe crude product crystallized from methanol

Sources & evidence

ORD record
ord-f76035956259415ca00a0a7107bbf1b2
Source dataset
uspto-grants-2001_07
Patent number
US06262059B1

Linked notes

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