2-Bromo-1-(3,4-dichlorophenyl)ethanone → HCID 13186365, compound
Reaction equation
[S:1]([CH2:5][C:6]([NH2:8])=[S:7])(=[O:4])(=[O:3])[NH2:2].[Cl:9][C:10]1[CH:11]=[C:12]([CH:17]=[CH:18][C:19]=1[Cl:20])[C:13](=O)[CH2:14]Br>C(O)C>[Cl:9][C:10]1[CH:11]=[C:12]([C:13]2[N:8]=[C:6]([CH2:5][S:1]([NH2:2])(=[O:4])=[O:3])[S:7][CH:14]=2)[CH:17]=[CH:18][C:19]=1[Cl:20]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of sulfamoylthioacetamide (7.7 g., 0.05 mol) and 3,4-dichlorophenacyl bromide (13.4 g., 0.05 mol) in ethanol (50 ml) was heated at reflux for 2 hours. After cooling and filtration there was obtained 11.5 g. of the desired intermediate, m.p. 187°-190° C.
Workup
- temperaturewas heated
- temperatureat reflux for 2 hours
- temperatureAfter cooling
- filtrationfiltration there
- customwas obtained 11.5 g
Sources & evidence
- ORD record
- ord-4bc93edf8b17496d9f2f00da02e1d16c
- Source dataset
- uspto-grants-1984_02
- Patent number
- US04431652
Reaction notes
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