N-Butylnicotinamide → HCID 20298115, compound
Reaction equation
[CH2:1]([NH:5][C:6](=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[N:9][CH:8]=1)[CH2:2][CH2:3][CH3:4]>C(O)(=O)C.[Pt]=O>[CH2:1]([NH:5][C:6]([CH:7]1[CH2:12][CH2:11][CH2:10][NH:9][CH2:8]1)=[O:13])[CH2:2][CH2:3][CH3:4]Participants
4
Reagents, catalysts & solvents 2
Procedure
N-n-Butylnicotinamide (7.0 g) in acetic acid (100 ml) was hydrogenated over platinum oxide at 50° and 50 p.s.i. The catalyst was removed by filtration, the filtrate evaporated and the residue treated with toluene and evaporated in vacuo. The residue in chloroform (50 ml) was washed with sodium bicarbonate solution (3×50 ml) the organic layer separated, dried (Na2SO4) and the solvent evaporated in vacuo to give as an oil 3-(N-n-butylcarbamoyl)piperidine (3.8 g).
Workup
- customThe catalyst was removed by filtration
- customthe filtrate evaporated
- additionthe residue treated with toluene
- customevaporated in vacuo
- washThe residue in chloroform (50 ml) was washed with sodium bicarbonate solution (3×50 ml) the organic layer
- customseparated
- dry with materialdried (Na2SO4)
- customthe solvent evaporated in vacuo
Sources & evidence
- ORD record
- ord-f3921004db8d40858362aff62f74763d
- Source dataset
- uspto-grants-1981_01
- Patent number
- US04243666
Reaction notes
Loading…