4-Amino-3-nitrobenzaldehyde → (3,4-Diaminophenyl)methanol

HRID 1389302

Reaction equation

HRID 1389302 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[N+:10]([O-])=O.[H][H]>[Ni].CO>[NH2:10][C:3]1[CH:4]=[C:5]([CH2:6][OH:7])[CH:8]=[CH:9][C:2]=1[NH2:1]

Participants

5

Reactant 2

HCID 132377034-Amino-3-nitrobenzaldehydeHCID 178418361HCID 178418361, compound

Product 1

HCID 12902832(3,4-Diaminophenyl)methanol

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of 8.3 parts of 4-amino-3-nitrobenzaldehyde in 200 parts of methanol is hydrogenated at normal pressure and at room temperature with 5 parts of Raney-nickel catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated, yielding 8.5 parts of 3,4-diaminobenzenemethanol as an oily residue.

Workup

  1. filtrationthe catalyst is filtered off
  2. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-15d94b4a92c5471dac6e531166565517
Source dataset
uspto-grants-1981_01
Patent number
US04243806

Linked notes

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