Sodium Hydroxide → (-)-Cystine

HRID 1389585

Reaction equation

HRID 1389585 reaction equation
Cl.Cl.[CH2:3]([S:9][S:10][CH2:11][C@H:12]([NH2:16])[C:13]([OH:15])=[O:14])[C@H:4]([NH2:8])[C:5]([OH:7])=[O:6].[OH-].[Na+]>O>[CH2:3]([S:9][S:10][CH2:11][C@H:12]([NH2:16])[C:13]([OH:15])=[O:14])[C@H:4]([NH2:8])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21121987L-Cystine dihydrochloride

Product 1

HCID 67678(-)-Cystine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

100 grams of L-cystine dihydrochloride were dissolved in 500 ml of water. The solution was adjusted to pH 3 by the addition of a concentrated aqueous solution of sodium hydroxide. As a result of this, the L-cystine separated out. The yield was 74 grams, corresponding to 94% based on the L-cystine dihydrochloride added. The L-cystine in a 5 percent solution in 1 N aqueous hydrochloric acid had a specific rotation of -217°. According to thin layer chromatography and column chromatography examination it was free from impurities.

Sources & evidence

ORD record
ord-8639b9d8e332499b9f823fd2b498e86b
Source dataset
uspto-grants-1981_01
Patent number
US04245117

Linked notes

Loading…