Dimethylamine → 5-Acetyl-2-dimethylaminobenzenesulphonamide
Reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7](Cl)=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:9]=1)(=[O:3])[CH3:2].[CH3:15][NH:16][CH3:17]>C(O)C>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([N:16]([CH3:17])[CH3:15])=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:9]=1)(=[O:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 5-acetyl-2-chloro-benzenesulphonamide (0.5 g) in ethanol (10 ml) and dimethylamine in ethanol (33%, 5 ml) was heated in a closed vessel on a steam bath for 16 hours. The solvents were removed under reduced pressure and the residue crystallised from ethanol to give the product 0.31 g, m.p. 184°-185°.
Workup
- temperaturewas heated in a closed vessel on a steam bath for 16 hours
- customThe solvents were removed under reduced pressure
- customthe residue crystallised from ethanol
Sources & evidence
- ORD record
- ord-1549e093f701489f816a05493178400c
- Source dataset
- uspto-grants-1979_02
- Patent number
- US04140713
Reaction notes
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