Aluminium lithium hydride → HCID 23033941, compound

Reaction equation

[N:1]1([C:7]2[S:8][C:9]3[C:15]([C:16](O)=[O:17])=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[N:1]1([C:7]2[S:8][C:9]3[C:15]([CH2:16][OH:17])=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 21226445Aluminium lithium hydride

HCID 23033856HCID 23033856, compound

Product 1

HCID 23033941HCID 23033941, compoundYield 92.1%

Procedure

Ethyl ester of 2-piperidinobenzothiazole-7-carboxylic acid (475 mg, 1.64 mmol) was reduced by using lithium aluminium hydride as in Preparation 2-3) to give 2-piperidinobenzothiazole-7-methanol (375 mg, 91%) as pale yellow crystals.

Workup

customas in Preparation 2-3)

Sources & evidence

ORD record: ord-b845774a6baf4daba8c37c342ae9dc46
Source dataset: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07345068B2

Reaction notes

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