4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole → 2-Cyclopropyl-4-(trifluoromethyl)-1-({2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl)-1H-indole-5-carbonitrile

HRID 139586

Reaction equation

HRID 139586 reaction equation
[CH:1]1([c:4]2[nH:5][c:6]3[cH:7][cH:8][c:9]([C:17]#[N:18])[c:10]([C:13]([F:14])([F:15])[F:16])[c:11]3[cH:12]2)[CH2:2][CH2:3]1.[Cl:19][CH2:20][c:21]1[n:22][c:23](-[c:26]2[cH:27][cH:28][c:29]([C:32]([F:33])([F:34])[F:35])[cH:30][cH:31]2)[s:24][cH:25]1>>[CH:1]1([c:4]2[n:5]([CH2:20][c:21]3[n:22][c:23](-[c:26]4[cH:27][cH:28][c:29]([C:32]([F:33])([F:34])[F:35])[cH:30][cH:31]4)[s:24][cH:25]3)[c:6]3[cH:7][cH:8][c:9]([C:17]#[N:18])[c:10]([C:13]([F:14])([F:15])[F:16])[c:11]3[cH:12]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 27366254-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazoleHCID 674044722-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 866207172-Cyclopropyl-4-(trifluoromethyl)-1-({2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl)-1H-indole-5-carbonitrile

Sources & evidence

ORD record
ord-70f067fa059148cabe40dfbd1fc5b2cb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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