Boronic Acid → 2-(Furan-2-yl)pyridine-4-carbaldehyde

Reaction equation

B(O)O.Br[C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][N:12]=1)[CH:8]=[O:9].[O:13]1[CH:17]=[CH:16][CH:15]=[C:14]1B(O)O>>[O:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][N:12]=1)[CH:8]=[O:9]

Participants

Reactant 3

HCID 61668Boronic Acid

HCID 2734357Furan-2-boronic acid

HCID 27629912-Bromo-4-pyridinecarboxaldehyde

Product 1

HCID 713330812-(Furan-2-yl)pyridine-4-carbaldehyde

Procedure

2-(furan-2-yl)isonicotinaldehyde was prepared using the general boronic acid coupling procedure for 2-bromoisonicotinaldehyde and furan-2-ylboronic acid (39.6 mg, 93.2 mg theoretical, 42.5%). LC-MS m/z 174.2 (M+1).

Sources & evidence

ORD record: ord-7f5112216af14d41b56af13d15d60c35
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08901145B2

Reaction notes

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