Boronic Acid → 3-Fluoro-6-(3-thienyl)-2-pyridinecarboxaldehyde
Reaction equation
B(O)O.Br[C:5]1[N:10]=[C:9]([CH:11]=[O:12])[C:8]([F:13])=[CH:7][CH:6]=1.[S:14]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15]1>>[F:13][C:8]1[C:9]([CH:11]=[O:12])=[N:10][C:5]([C:16]2[CH:17]=[CH:18][S:14][CH:15]=2)=[CH:6][CH:7]=1Participants
4
Procedure
3-fluoro-6-(thiophen-3-yl)picolinaldehyde was prepared using the general boronic acid coupling procedure for 6-bromo-3-fluoropicolinaldehyde and thiophen-3-ylboronic acid (80.5 mg, 101.5 mg theoretical, 79.3%). LC-MS m/z 208.2 (M+1).
Sources & evidence
- ORD record
- ord-7935a1b4cf954cc2bd0e2a378124b41f
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08901145B2
Reaction notes
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