Thionyl Chloride → HCID 57707975, compound
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:8]([CH2:19]O)=[CH:7]2.O=S(Cl)[Cl:23]>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:8]([CH2:19][Cl:23])=[CH:7]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared according to Procedure C using (8-chloro-2-phenoxyquinolin-3-yl)-methanol (1.0 eq) and SOCl2 (5 eq) in CHCl3 (0.25M) at rt. 8-chloro-3-(chloromethyl)-2-phenoxyquinoline was obtained after purification as a yellow oil.
Workup
- customPrepared
- customat rt
Sources & evidence
- ORD record
- ord-bbb553ada22c47e9a6de2daa08251bce
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08901135B2
Reaction notes
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