HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Thionyl Chloride → 2-Ethoxycarbonyloxy-5-octanoylbenzoyl chloride

HRID 1398277
Notes
Print preview

Reaction equation

HRID 1398277 reaction equation
[CH2:1]([O:3][C:4]([O:6][C:7]1[CH:15]=[CH:14][C:13]([C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:12][C:8]=1[C:9](O)=[O:10])=[O:5])[CH3:2].S(Cl)([Cl:27])=O>C1(C)C=CC=CC=1.N1C=CC=CC=1>[CH2:1]([O:3][C:4]([O:6][C:7]1[CH:15]=[CH:14][C:13]([C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:12][C:8]=1[C:9]([Cl:27])=[O:10])=[O:5])[CH3:2]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 24386Thionyl ChlorideHCID 86680239HCID 86680239, compound

Product 1

HCID 866802402-Ethoxycarbonyloxy-5-octanoylbenzoyl chlorideYield 98.3%

Reagents, catalysts & solvents 2

HCID 1049PyridineCatalystHCID 1140TolueneSolvent

Conditions

Temperature
55 °C

Procedure

5.59 g (16.6 mmol) of 2-ethoxycarbonyloxy-5-octanoylbenzoic acid are dissolved in 56 ml of toluene with a few drops of pyridine. 1.45 ml (20 mmol) of thionyl chloride are added dropwise and the mixture is stirred at 55° C. for 14 hours and then concentrated to dryness. 5.79 g of 2-ethoxycarbonyloxy-5-octanoylbenzoyl chloride are obtained in a yield of 98%.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-77a08b6ecbfd45ac84b43d4a568e9397
Source dataset
uspto-grants-2014_12
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08901357B2

Reaction notes

Loading…

On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes