2-Thiophenecarboxaldehyde, 5-chloro- → HCID 59053593, compound

Reaction equation

[Cl-].[Cl:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[NH:13][CH2:14][CH2:15][NH3+:16].[Cl:17][C:18]1[S:22][C:21]([CH:23]=O)=[CH:20][CH:19]=1>>[Cl:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[NH:13][CH2:14][CH2:15][NH:16][CH2:23][C:21]1[S:22][C:18]([Cl:17])=[CH:19][CH:20]=1

Participants

Reactant 2

HCID 817002-Thiophenecarboxaldehyde, 5-chloro-

HCID 68152103HCID 68152103, compound

Product 1

HCID 59053593HCID 59053593, compoundYield 52%

Procedure

Prepared from 2-[(1-chloronaphthalen-2-yl)amino]ethanaminium chloride and 5-chlorothiophene-2-carbaldehyde in 52% yield as a white oil.

Sources & evidence

ORD record: ord-39f96555d13c42fa8c0d21ab2114d13e
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08906946B2

Reaction notes

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