2-Thiophenecarboxaldehyde, 5-chloro- → HCID 59053600, compound

Reaction equation

[Cl-].[F:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[O:13][CH2:14][CH2:15][NH3+:16].[Cl:17][C:18]1[S:22][C:21]([CH:23]=O)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[S:22][C:21]([CH2:23][NH:16][CH2:15][CH2:14][O:13][C:4]2[CH:5]=[CH:6][C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:3]=2[F:2])=[CH:20][CH:19]=1

Participants

Reactant 2

HCID 817002-Thiophenecarboxaldehyde, 5-chloro-

HCID 68151396HCID 68151396, compound

Product 1

HCID 59053600HCID 59053600, compoundYield 71%

Procedure

Prepared from 2-[(1-fluoronaphthalen-2-yl)oxy]ethanaminium chloride and 5-chlorothiophen-2-carbaldehyde in 71% yield as a slightly white oil.

Sources & evidence

ORD record: ord-ca0d4e8d050e49bba39363f68f72c477
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08906946B2

Reaction notes

Loading…