1-Methyl-1H-pyrrole-2-carbaldehyde → HCID 59053659, compound

Reaction equation

[Cl-].[F:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[O:13][CH2:14][CH2:15][NH3+:16].[CH3:17][N:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[CH:23]=O>>[F:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[O:13][CH2:14][CH2:15][NH:16][CH2:23][C:19]1[N:18]([CH3:17])[CH:22]=[CH:21][CH:20]=1

Participants

Reactant 2

HCID 145041-Methyl-1H-pyrrole-2-carbaldehyde

HCID 68151396HCID 68151396, compound

Product 1

HCID 59053659HCID 59053659, compoundYield 65%

Procedure

Prepared from 2-[(1-fluoronaphthalen-2-yl)oxy]ethanaminium chloride and 1-methyl-1H-pyrrole-2-carbaldehyde in 65% yield as a yellow oil.

Sources & evidence

ORD record: ord-ccd03782fb31419c8e1fd57e7b82aa8f
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08906946B2

Reaction notes

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