2-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one → 1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]-1,4-diazepane

HRID 1401844

Reaction equation

HRID 1401844 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15](=[S:17])[NH2:16])[CH2:10][CH2:9]1)=O)(C)(C)C.Br[CH2:19][C:20]([C:22]1[CH:31]=[CH:30][C:29]2[C:28]([CH3:33])([CH3:32])[CH2:27][CH2:26][C:25]([CH3:35])([CH3:34])[C:24]=2[CH:23]=1)=O>>[CH3:32][C:28]1([CH3:33])[CH2:27][CH2:26][C:25]([CH3:34])([CH3:35])[C:24]2[CH:23]=[C:22]([C:20]3[N:16]=[C:15]([N:11]4[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]4)[S:17][CH:19]=3)[CH:31]=[CH:30][C:29]1=2

Participants

3

Reactant 2

HCID 28013372-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-oneHCID 866718274-Thiocarbamoyl-1,4-diazepane-1-carboxylic acid tert-butyl ester

Product 1

HCID 533115431-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]-1,4-diazepane

Procedure

The preparation is carried out as already described starting from 1.12 g (4.55 mmol) of 4-thiocarbamoyl-1,4-diazepane-1-carboxylic acid tert-butyl ester from step a and 1.93 g (6.25 mmol) of 2-bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone.

Sources & evidence

ORD record
ord-afa24e65d6414065ab068d5c42c7e3ee
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Linked notes

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