Thionyl Chloride → HCID 12873573, compound
Reaction equation
S(Cl)([Cl:3])=O.O[CH2:6][N:7]1[C:11]([CH3:13])([CH3:12])[C:10](=[O:14])[NH:9][C:8]1=[O:15]>C(Cl)Cl>[Cl:3][CH2:6][N:7]1[C:11]([CH3:13])([CH3:12])[C:10](=[O:14])[NH:9][C:8]1=[O:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
0.69 ml Thionyl chloride was added to a solution of 500 mg 1-Hydroxymethyl-5,5-dimethyl-imidazolidine-2,4-dione in 5 ml DCM at 0° C. for 30 minutes, then left to stir at 25° C. for 16 hours. The mixture was evaporated to dryness and used crude in the synthesis of example 23.
Workup
- waitleft
- customThe mixture was evaporated to dryness
- customin the synthesis of example 23
Sources & evidence
- ORD record
- ord-609eed20e0a14a0cb47a0ebc68b40883
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08912173B2
Reaction notes
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