Dimethyl malonate → HCID 66759855, compound

Reaction equation

[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:17])[CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[C:18]([O:25][CH3:26])(=[O:24])[CH2:19][C:20]([O:22][CH3:23])=[O:21]>>[I:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:17])[CH2:9][CH:10]([CH:19]([C:18]([O:25][CH3:26])=[O:24])[C:20]([O:22][CH3:23])=[O:21])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 7943Dimethyl malonate

HCID 345252HCID 345252, compound

Product 1

HCID 66759855HCID 66759855, compound

Procedure

By a procedure similar to that of example 1.59.2, starting from 1-(4-iodophenyl)-3-phenylprop-2-en-1-one and dimethyl malonate, dimethyl 2-(3-(4-iodophenyl)-3-oxo-1-phenylpropyl)malonate was obtained as yellowish solid.

Sources & evidence

ORD record: ord-ab7ac2e7662d4736b011cb4ba38e129d
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08912186B2

Reaction notes

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