Acetic Anhydride → HCID 86654326, compound

Reaction equation

[Br:1][C:2]1[C:8]([O:9][CH3:10])=[C:7]([Br:11])[CH:6]=[C:5]([F:12])[C:3]=1[NH2:4].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[Br:1][C:2]1[C:8]([O:9][CH3:10])=[C:7]([Br:11])[CH:6]=[C:5]([F:12])[C:3]=1[NH:4][C:13](=[O:15])[CH3:14]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 86654325HCID 86654325, compound

Product 1

HCID 86654326HCID 86654326, compoundYield 79.2%

Procedure

Compound 8-5 (212.7 g, 0.711 mol) was added to acetic anhydride (200 mL) in one portion at 20° C. The reaction mixture was stirred for 30 minutes and then was filtered to get 8-6 (192 g, 79.2%) as a white solid.

Workup

filtrationwas filtered

Sources & evidence

ORD record: ord-1ce35c1fb7da4a5cab3562920946b611
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08912220B2

Reaction notes

Loading…