Thionyl Chloride → 3-Iodo-2-methoxy-benzoyl chloride
Reaction equation
[I:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].S(Cl)([Cl:15])=O>>[I:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([Cl:15])=[O:6]Participants
3
Conditions
- Temperature
- 82 °C
Procedure
To 3-iodo-2-methoxy-benzoic acid (8.29 g, 29.8 mmol) was added thionyl chloride (15 mL). The resulting solution was stirred for 2 minutes then heated to 82° C. and stirred at this temperature for 30 minutes. The solution was then concentrated under reduced pressure to give the title compound. This material was used without further purification.
Workup
- stirringstirred at this temperature for 30 minutes
- concentrationThe solution was then concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-a0dfb4ece7c749ea94dcf912cc5a2e6c
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08912169B2
Reaction notes
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