(3-Carbamoylphenyl)boronic acid → 3-{1-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[3,2-b]pyridin-6-yl}benzamide
Reaction equation
Br[C:2]1[CH:3]=[C:4]2[N:10]([O:11][CH:12]([C:14]3[C:19]([Cl:20])=[CH:18][CH:17]=[C:16]([F:21])[C:15]=3[Cl:22])[CH3:13])[CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1.[C:23]([C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][CH:31]=1)(=[O:25])[NH2:24]>>[Cl:22][C:15]1[C:16]([F:21])=[CH:17][CH:18]=[C:19]([Cl:20])[C:14]=1[CH:12]([O:11][N:10]1[C:4]2[C:5](=[N:6][CH:7]=[C:2]([C:30]3[CH:31]=[C:26]([CH:27]=[CH:28][CH:29]=3)[C:23]([NH2:24])=[O:25])[CH:3]=2)[CH:8]=[CH:9]1)[CH3:13]Participants
3
Procedure
The entitled compound was prepared from 6-bromo-1-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[3,2-b]pyridine and (3-carbamoylphenyl)boronic acid according to the procedure described in example 4.
Sources & evidence
- ORD record
- ord-e4c8bc0cb0714d0f9c1f1a68b0111b13
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08912330B2
Reaction notes
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