2,3,5-Trifluorobenzyl alcohol → 4-{4-Fluoro-2-[(2,3,5-trifluorobenzyl)oxy]phenyl}-N-{3-[(methylsulfonyl)methyl]-phenyl}-1,3,5-triazin-2-amine

HRID 1405253

Reaction equation

HRID 1405253 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[F:27][C:28]1[C:35]([F:36])=[CH:34][C:33]([F:37])=[CH:32][C:29]=1[CH2:30][OH:31]>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=3)[N:10]=2)=[C:2]([O:31][CH2:30][C:29]2[CH:32]=[C:33]([F:37])[CH:34]=[C:35]([F:36])[C:28]=2[F:27])[CH:7]=1

Participants

3

Reactant 2

HCID 27770302,3,5-Trifluorobenzyl alcoholHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 665760564-{4-Fluoro-2-[(2,3,5-trifluorobenzyl)oxy]phenyl}-N-{3-[(methylsulfonyl)methyl]-phenyl}-1,3,5-triazin-2-amine

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (70 mg; 0.184 mmol), intermediate 42.1, and 2,3,5-trifluorobenzyl alcohol (119 mg; 0.736 mmol), example 84 was prepared analogously to the procedure for the preparation of example 42.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 42

Sources & evidence

ORD record
ord-c140f3d4ab1b492d98feddd62f9b30b4
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Linked notes

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