Allyl bromide → 3-allyl-1-methyl-1H-quinazoline-2,4-dione

HRID 1405614

Reaction equation

[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[NH:4][C:3]1=[O:13].[CH2:14](Br)[CH:15]=[CH2:16]>>[CH2:16]([N:4]1[C:5](=[O:12])[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[N:2]([CH3:1])[C:3]1=[O:13])[CH:15]=[CH2:14]

Participants

Reactant 2

HCID 7841Allyl bromide

HCID 11788Glycosmicine

Product 1

HCID 867230523-allyl-1-methyl-1H-quinazoline-2,4-dioneYield 58%

Procedure

Starting from 1-methylquinazoline-2,4(1H,3H)-dione and allyl bromide and using Procedure E, the title intermediate was obtained as a colourless solid (0.125 g; 58% yield).

Sources & evidence

ORD record: ord-e4f849d8d7f54fda90fb3d8f351f9e0a
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08916573B2

Linked notes

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