N-propylisatoic anhydride → HCID 71254624, compound

HRID 1405618

Reaction equation

HRID 1405618 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][C@H:5]1[O:9][C:8](=[O:10])[N:7]([C:11]2[CH:12]=[CH:13][C:14]3[S:19][CH2:18][C:17](=[O:20])[NH:16][C:15]=3[CH:21]=2)[CH2:6]1.[CH2:22]([N:25]1C(=O)O[C:28](=[O:29])[C:27]2=[CH:33][CH:34]=[CH:35][CH:36]=[C:26]12)[CH2:23][CH3:24]>>[O:10]=[C:8]1[N:7]([C:11]2[CH:12]=[CH:13][C:14]3[S:19][CH2:18][C:17](=[O:20])[NH:16][C:15]=3[CH:21]=2)[CH2:6][C@@H:5]([CH2:4][CH2:3][CH2:2][NH:1][C:28](=[O:29])[C:27]2[CH:33]=[CH:34][CH:35]=[CH:36][C:26]=2[NH:25][CH2:22][CH2:23][CH3:24])[O:9]1

Participants

3

Reactant 2

HCID 3933296N-propylisatoic anhydrideHCID 673035876-[(R)-5-(3-amino-propyl)-2-oxo-oxazolidin-3-yl]-4H-benzo[1,4]thiazin-3-one

Product 1

HCID 71254624HCID 71254624, compoundYield 67%

Procedure

Starting from 6-[(R)-5-(3-amino-propyl)-2-oxo-oxazolidin-3-yl]-4H-benzo[1,4]thiazin-3-one (described in WO 2010/041219) and N-propylisatoic anhydride and using Procedure A, the title compound was obtained as a beige solid (77 mg; 67% yield).

Sources & evidence

ORD record
ord-4913899472e948bf964ba724203b2f11
Source dataset
uspto-grants-2014_12
Patent number
US08916573B2

Linked notes

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