Methanol → HCID 53663529, compound
Reaction equation
C([O:8][C:9]([NH:11][CH2:12][CH2:13][S:14]([NH2:17])(=[O:16])=[O:15])=O)C1C=CC=CC=1.CO>[Pd].C(O)=O>[CH:9]([NH:11][CH2:12][CH2:13][S:14]([NH2:17])(=[O:16])=[O:15])=[O:8]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
In a reaction flask, 10.3 g of 2-benzyloxyformamidoethylsulfonamide, 10% Pd/C (3.0 g) and 600 ml of methanol were added. The mixture was stirred at room temperature overnight under hydrogen atmosphere, added with 35 ml of formic acid, stirred for 30 min, filtered, and concentrated under a reduced pressure to obtain 5.6 g of oily product, yield 93%.
Workup
- stirringstirred for 30 min
- filtrationfiltered
- concentrationconcentrated under a reduced pressure
Sources & evidence
- ORD record
- ord-295e840ebcbc4de99c2ded232ca6a24d
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08916574B2
Reaction notes
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