Ammonia → HCID 43189234, compound

HRID 1406342

Reaction equation

HRID 1406342 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14](=O)[CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[H][H].[NH3:21]>[Ni]>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]([NH2:21])[CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 27772531-(4-(4-Methoxyphenoxy)phenyl)ethan-1-oneHCID 178418361HCID 178418361, compound

Product 1

HCID 43189234HCID 43189234, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst2×

Conditions

Temperature
50 °C

Procedure

78 mg (0.32 mmol) of 1-[4-(4-methoxy-phenoxy)-phenyl]-ethanone were dissolved in 10 ml of 7M methanolic ammonia and combined with 50 mg of Raney nickel. The mixture was shaken for 6 h at 50° C. and 3 bar hydrogen pressure. Raney nickel was added twice more and hydrogenation was continued for 2 h and 6 h under the same conditions. The catalyst was removed by suction filtering and the residue was evaporated down.

Workup

  1. waithydrogenation was continued for 2 h and 6 h under the same conditions
  2. customThe catalyst was removed by suction
  3. filtrationfiltering
  4. customthe residue was evaporated down

Sources & evidence

ORD record
ord-e1c080c3ddbd4ac1939198ac2b945bd3
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Linked notes

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