Nitric Acid → 4-Acetamido-2-fluoro-5-nitrobenzoic acid
Reaction equation
[C:1]([NH:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([F:14])[CH:6]=1)(=[O:3])[CH3:2].S(=O)(=O)(O)O.[N+:20]([O-])([OH:22])=[O:21]>>[C:1]([NH:4][C:5]1[C:13]([N+:20]([O-:22])=[O:21])=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([F:14])[CH:6]=1)(=[O:3])[CH3:2]Participants
4
Procedure
Prepared analogously to example 83b from 4-acetylamino-2-fluoro-benzoic acid, conc. sulphuric acid and conc. nitric acid.
Sources & evidence
- ORD record
- ord-555f893915514bd6a31ac1cded01128b
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08916599B2
Reaction notes
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