Thionyl Chloride → HCID 58424408, compound

Reaction equation

[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][CH2:8][CH2:9][C:10](O)=[O:11])=[CH:4][CH:3]=1.O=S(Cl)[Cl:17]>>[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][CH2:8][CH2:9][C:10]([Cl:17])=[O:11])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 23844544-(4-Bromophenoxy)butanoic acid

Product 1

HCID 58424408HCID 58424408, compoundYield 67%

Procedure

4-(4-Bromophenoxy)butanoic acid (39 g, 25.6 mmol) was dissolved in SOCl2 (100 ml) mixture was heated to refluxed overnight. the mixture was concentrated in vacuo to give 4-(4-bromophenoxy)butanoyl chloride (27.6 g, 67%).

Workup

temperaturewas heated
temperatureto refluxed overnight
concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record: ord-42fd8a53005d49de871f14990f2f29aa
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921359B2

Reaction notes

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