HCID 70981716, compound → HCID 70981750, compound
Reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([O:9]CC2C=CC=CC=2)=[O:8])[N:4]=[C:3]1[C:17]1[CH:18]=[N:19][N:20]([CH3:22])[CH:21]=1>CCO.[Pd]>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[N:4]=[C:3]1[C:17]1[CH:18]=[N:19][N:20]([CH3:22])[CH:21]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Into a flask containing a solution of benzyl 1-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1H-imidazole-4-carboxylate (1 g, 3.4 mmol) in EtOH (25 ml), 10% Pd/C (100 mg) was added at RT. The resulting mixture was stirred at RT under H2 atmosphere for 3 h. The reaction mixture was filtered through a celite bed and the filtrate was concentrated. The residue was triturated twice from diethyl ether. Yield 500 mg. LC-MS: [M+1]=207.04.
Workup
- additionwas added at RT
- filtrationThe reaction mixture was filtered through a celite bed
- concentrationthe filtrate was concentrated
- customThe residue was triturated twice from diethyl ether
Sources & evidence
- ORD record
- ord-9e9e02bf0d6a4d9889cb70bc7b1d8dbc
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08921378B2
Reaction notes
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