Triacetoxyperiodinane → 1-(5-Ethyl-pyrazin-2-yl)-piperidin-4-one
Reaction equation
[CH2:1]([C:3]1[N:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][CH:12]([OH:15])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>ClCCl>[CH2:1]([C:3]1[N:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The title compound is prepared from 1-(5-ethyl-pyrazin-2-yl)-piperidin-4-ol by oxidation with Dess-Martin periodinane in dichloromethane at room temperature. LC (method 7): tR=0.73 min; Mass spectrum (ESI+): m/z=206 [M+H]+.
Sources & evidence
- ORD record
- ord-5d7195145e374b18957f84173dafc4dd
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08921398B2
Reaction notes
Loading…