5-(methoxymethyl)-1-methyl-3-nitro-1H-pyrazole → 5-(Methoxymethyl)-1-methyl-1H-pyrazol-3-amine
Reaction equation
[CH3:1][O:2][CH2:3][C:4]1[N:8]([CH3:9])[N:7]=[C:6]([N+:10]([O-])=O)[CH:5]=1>[Pd].C(O)C>[CH3:1][O:2][CH2:3][C:4]1[N:8]([CH3:9])[N:7]=[C:6]([NH2:10])[CH:5]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A 250-mL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with 336a (4.0 g, 23 mmol), Pd/C (1.0 g), and ethanol (100 mL). The mixture was hydrogenated at room temperature for 15 h. It was then filtered and the filtrate was concentrated under reduced pressure to afford 336b as a yellow oil (3.3 g, 99%), which was used in the next step without further purification. MS-ESI: [M+H]+ 142.
Workup
- customA 250-mL single-neck round-bottomed flask equipped with a magnetic stirrer
- filtrationIt was then filtered
- concentrationthe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-b6129de7e2ea40a99e84704883072576
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08921353B2
Reaction notes
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