Ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxohexanoate → HCID 67008513, compound

HRID 1412224

Reaction equation

HRID 1412224 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([C:22](=O)[CH2:23][CH2:24][CH3:25])[C:17](OCC)=[O:18])=[CH:11][CH:10]=1)#[N:2].[CH3:27][O:28][CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]1[NH:35][C:36]1[NH:40][C:39]([CH3:41])=[N:38][N:37]=1>>[CH3:27][O:28][CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]1[N:35]1[C:17](=[O:18])[C:16]([CH2:15][C:12]2[CH:13]=[CH:14][C:9]([C:4]3[C:3]([C:1]#[N:2])=[CH:8][CH:7]=[CH:6][CH:5]=3)=[CH:10][CH:11]=2)=[C:22]([CH2:23][CH2:24][CH3:25])[N:37]2[N:38]=[C:39]([CH3:41])[N:40]=[C:36]12

Participants

3

Reactant 2

HCID 10020734Ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxohexanoateHCID 178489584HCID 178489584, compound

Product 1

HCID 67008513HCID 67008513, compoundYield 46%

Conditions

Temperature
250 °C

Procedure

A mixture of ethyl 2-[(2′-cyanobiphenyl-4-yl)methyl]-3-oxohexanoate (0.83 g) and N-(2-methoxycyclohexyl)-5-methyl-4H-1,2,4-triazol-3-amine (0.25 g) was stirred at 250° C. for 15 min under microwave irradiation. The obtained reaction mixture was purified by silica gel column chromatography to give the title compound as a colorless solid (0.27 g, 46%).

Workup

  1. customThe obtained reaction mixture
  2. customwas purified by silica gel column chromatography

Sources & evidence

ORD record
ord-965d62e8cee447eb948d86de7fc22381
Source dataset
uspto-grants-2014_12
Patent number
US08921379B2

Linked notes

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