4-Thioureidoanisole → N-(2-Ethoxyphenyl)thiourea

HRID 1414101

Reaction equation

HRID 1414101 reaction equation
CO[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([NH2:12])=[S:11])=[CH:5][CH:4]=1.[CH2:13]([O:15]C1C=CC(NC(N)=S)=CC=1)[CH3:14]>>[CH2:13]([O:15][C:7]1[C:6]([NH:9][C:10]([NH2:12])=[S:11])=[CH:5][CH:4]=[CH:3][CH:8]=1)[CH3:14]

Participants

3

Reactant 2

HCID 6675494-ThioureidoanisoleHCID 8535694-Ethoxyphenylthiourea

Product 1

HCID 2758773N-(2-Ethoxyphenyl)thioureaYield 95.6%

Procedure

The reaction is carried out as described in the preceding Example with the exception that instead of 4-methoxyphenylthiourea the equimolar amount of 4-ethoxyphenylthiourea is used. 6-Ethoxy-phenylthiourea melting at 174° C. is obtained in a 95.6% yield and with the same good purity.

Sources & evidence

ORD record
ord-2fdbf46a3d0d48e5b00f370b9d5b64a6
Source dataset
uspto-grants-1981_02
Patent number
US04252963

Linked notes

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