Dimethylamine → HCID 21486904, compound
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([O-:10])=O.[CH3:11][NH:12][CH3:13].[CH2:14]([OH:16])C>>[CH3:14][O:16][CH:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:8]([N:12]([CH3:13])[CH3:11])=[O:10]Participants
4
Procedure
A mixture of 18.1 g. of methyl 2-methoxy-2-(2-pyridylacetate and 10 g. of dimethylamine in ethanol is stirred at room temperature for 26 hours. The mixture is concentrated, dissolved in chloroform and extracted with brine. The organic phase is dried over magnesium sulfate and filtered and the solvent is removed under reduced pressure to give 2-methoxy-N,N-dimethyl-2-(2-pyridyl)acetamide.
Workup
- additionA mixture of 18.1 g
- concentrationThe mixture is concentrated
- dissolutiondissolved in chloroform
- extractionextracted with brine
- dry with materialThe organic phase is dried over magnesium sulfate
- filtrationfiltered
- customthe solvent is removed under reduced pressure
Sources & evidence
- ORD record
- ord-b82a45d711a04f799b71095365eda031
- Source dataset
- uspto-grants-1977_01
- Patent number
- US04001241
Reaction notes
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