6-Methyl-8-oxo-ergoline → 6-Methyl-8-(2-isopropoxy-5-pyridylamino)ergoline
Reaction equation
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][N:6]=1)([CH3:3])[CH3:2].[CH3:12][N:13]1[C@H:27]2[C@@H:17]([C:18]3[CH:19]=[CH:20][CH:21]=[C:22]4[C:28]=3[C:25]([CH2:26]2)=[CH:24][NH:23]4)[CH2:16][C:15](=O)[CH2:14]1>[Pd]>[CH3:12][N:13]1[C@H:27]2[C@@H:17]([C:18]3[CH:19]=[CH:20][CH:21]=[C:22]4[C:28]=3[C:25]([CH2:26]2)=[CH:24][NH:23]4)[CH2:16][CH:15]([NH:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][CH:1]([CH3:3])[CH3:2])=[N:6][CH:7]=2)[CH2:14]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The following compounds (isomers Ia and Ib) are obtained in a manner analogous to that described in Example 3, from 2-isopropoxy-5-aminopyridine and 6-methyl-8-oxo-ergoline in the presence of palladium: