6-Methyl-8-oxo-ergoline → 6-Methyl-8-(2-tert.butoxy-5-pyridylamino)ergoline
Reaction equation
[C:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][N:7]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:13][N:14]1[C@H:28]2[C@@H:18]([C:19]3[CH:20]=[CH:21][CH:22]=[C:23]4[C:29]=3[C:26]([CH2:27]2)=[CH:25][NH:24]4)[CH2:17][C:16](=O)[CH2:15]1>[Pd]>[CH3:13][N:14]1[C@H:28]2[C@@H:18]([C:19]3[CH:20]=[CH:21][CH:22]=[C:23]4[C:29]=3[C:26]([CH2:27]2)=[CH:25][NH:24]4)[CH2:17][CH:16]([NH:12][C:9]2[CH:10]=[CH:11][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[N:7][CH:8]=2)[CH2:15]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The following compounds (isomers Ia and Ib) are obtained in a manner analogous to that described in Example 3, from 2-tert.butoxy-5-aminopyridine and 6-methyl-8-oxo-ergoline in the presence of palladium: