Acetic Acid → HCID 67582831, compound
Reaction equation
[OH:1][CH2:2][CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1.[C:21]([OH:24])(=[O:23])[CH3:22]>CO>[C:21]([OH:24])(=[O:23])[CH3:22].[OH:1][CH2:2][CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 4-[(2-hydroxyethyl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 42) (1.2 g) in methanol (20 ml) is added acetic acid (0.3 g), and the mixture is evaporated to dryness under reduced pressure. The residue is recrystallized from acetonitrile to give 4-[(2-hydroxyethyl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (0.2 g) as crystals.