2-(4-amino-2-chlorophenoxy)-N,N-dimethylacetamide → HCID 70344901, compound
Reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:16][C:17]1[CH:18]=[C:19]([CH:21]=[CH:22][C:23]=1[O:24][CH2:25][C:26](=[O:30])[N:27]([CH3:29])[CH3:28])[NH2:20]>>[Cl:16][C:17]1[CH:18]=[C:19]([CH:21]=[CH:22][C:23]=1[O:24][CH2:25][C:26](=[O:30])[N:27]([CH3:28])[CH3:29])[NH:20][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[N:5]=[CH:4][N:3]=1Participants
3
Procedure
Using an analogous procedure to that described in Example 18, 4-chloro-6-(3'-methylanilino)pyrimidine (0.33 g) was reacted with 3-chloro-4-(N,N-dimethylcarbamoylmethoxy)aniline to give 4-[3'-chloro-4'-(N,N-dimethylcarbamoylmethoxy)anilino]6-(3'-methylanilino)pyrimidine is 46% yield, m.p. 190°-193° C.;
Sources & evidence
- ORD record
- ord-ac20406ce79446c39c80da31a33a033c
- Source dataset
- uspto-grants-1999_03