Benzene → 4-(4-Ethoxyphenyl)-2-fluoro-4-methylpent-2-enyl acetate
Reaction equation
[Cl-].[C:2]([O-:5])(=[O:4])[CH3:3].[CH2:6]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([CH3:22])([CH3:21])[CH:16]=[C:17]([F:20])[CH2:18]O)=[CH:11][CH:10]=1)[CH3:7].C1C=CC=CC=1>N1C=CC=CC=1>[C:2]([O:5][CH2:18][C:17]([F:20])=[CH:16][C:15]([C:12]1[CH:11]=[CH:10][C:9]([O:8][CH2:6][CH3:7])=[CH:14][CH:13]=1)([CH3:21])[CH3:22])(=[O:4])[CH3:3]Participants
5
Procedure
The method of Example 11 was repeated using acetate chloride (0.17 ml), 4-(4-ethoxyphenyl)-2-fluoro-4-methylpent-2-enol (Example 9) (86 mg), benzene (4 ml) and pyridine (0.04 ml) to yield the title compound (0.1 g, 99%).
Sources & evidence
- ORD record
- ord-6eabaceaecac46b6af189f4b22b0bdbc
- Source dataset
- uspto-grants-1999_03
- Patent number
- US05880162
Reaction notes
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