5-Nitrothiophene-2-carboxaldehyde → (E)-3-(2-nitrothien-5-yl)-2-(thien-3-ylsulfonyl)acrylonitrile

Reaction equation

[N+:1]([C:4]1[S:5][C:6]([CH:9]=O)=[CH:7][CH:8]=1)([O-:3])=[O:2].[S:11]1[CH:15]=[CH:14][C:13]([S:16]([CH2:19][C:20]#[N:21])(=[O:18])=[O:17])=[CH:12]1>>[N+:1]([C:4]1[S:5][C:6](/[CH:9]=[C:19](/[S:16]([C:13]2[CH:14]=[CH:15][S:11][CH:12]=2)(=[O:18])=[O:17])\[C:20]#[N:21])=[CH:7][CH:8]=1)([O-:3])=[O:2]

Participants

Reactant 2

HCID 782815-Nitrothiophene-2-carboxaldehyde

HCID 27975192-(3-Thienylsulfonyl)acetonitrile

Product 1

HCID 67582698(E)-3-(2-nitrothien-5-yl)-2-(thien-3-ylsulfonyl)acrylonitrile

Procedure

Reaction of 2-nitrothiophen-5-carboxaldehyde and thien-3-ylsulfonylacetonitrile as in Example 1 gave (E)-3-(2-nitrothien-5-yl)-2-(thien-3-ylsulfonyl)acrylonitrile

Sources & evidence

ORD record: ord-6f00062dfc3245369dd6fd3fb9a36a75
Source dataset: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05886195

Reaction notes

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